摘要
目的探讨合并自主神经病变非肥胖糖尿病患者睡眠呼吸紊乱(sleep-disordered breathing,SDB)的特点及发生机制。方法对22例男性非肥胖糖尿病患者和对照组8例正常人的PSG结果进行对比分析,其中14例合并自主神经病变(DAN+),8例无自主神经病变(DAN-)。结果4例DAN+患者AI≥5,5例DAN+患者AHI≥10,DAN-及对照组无一例出现SDB。DAN+患者主要表现为发生于快速动眼期的阻塞性呼吸紊乱。10例DAN+患者在快速动眼期MLSaO2<90%。结论合并自主神经病变的糖尿病患者OSA的发生率明显高于普通人群,OSA的发生机制可能是支配上气道反射的自主神经病变所致。
Objective To assess the occurrence and nature of sleep- disordered breathing （SDB）. Methods 22 adult, nonobese diabetics patients were analyzed by polysomnography （PSG） method, of the DM 14 with autonomic neuropathy （ DAN ＋ ） and 8 without autonomic neuropathy （ DAN - ）. Ten normal subjects were studied as controls. Results In contrast to DAN - and controls, who did not show SDB,5 DAN ＋ had an apnoea/hypopnoea index（AHI） 910 and 4 DAN ＋ had an apnoea index （AI） /〉5. All the events were obstructive, occurring mainly during rapid eye movement （REM） sleep. 10 DAN ＋ exhibited a mean lowest oxygen saturation （MLSaO2） K90% during REM sleep. Conclusion A frequency of OSA in adult, nonobese male DAN ＋ appears abnormally high compared with figures reported from the general population, possibly due to alterations of the autonomic nervous fibres related to an impairment of the upper airway reflexes.
出处
《医药论坛杂志》
2007年第2期44-45,共2页
Journal of Medical Forum
关键词
糖尿病
自主神经病变
睡眠呼吸紊乱
Diabetes mellitus
Autonomic neuropathy
Sleep - disordered breathing
