摘要
目的探讨CerbB2和P53在子宫内膜癌中的表达的意义以及二者间的关系。方法应用免疫组织化学法回顾性分析了85例子宫内膜癌患者的石蜡标本中CerbB2和P53蛋白的表达,并对其生存期进行随访。结果CerbB2和P53表达的阳性率分别为27.06%、45.88%;CerbB2阳性表达者5年生存率为52.38%,阴性表达者为73.65%,差异有显著意义(P<0.05);P53阳性表达者5年生存率为59.25%,阴性表达者为84.36%,差异有显著意义(P<0.05);P53,CerbB2和P53表达间无相关性。结论CerbB2和P53在子宫内膜癌中的表达与内膜癌的生物学行为有关,可作为子宫内膜癌预后的指标,指导子宫内膜癌术后的治疗。
Objective To investigate the clinical and pathological significances of P^53 and CerbB2 expressions in endometrium carcinoma and the relationship between them. Methods The expressions of P^53 and CerbB2 were retrospectively studied by immunohistochemical method. Their survival rate was surveyed in the following 5 years. Results The positive rates of P^53 and CerbB2 expressions were 27.06% and 45.88% respectively. The five year survival rates of the positive and negative cases were 52.38% and 73.65% respectively（P 〈0.01 ）. The survival rates of cases of positive and negative P^53 expressions were 59.25% and 84.36% , respectively （ P 〈 0.05 ）. No correlation was found between the expressions of P^53 and CerbB2. Conclusion P^53 and CerbB2 expressions in endometrium carcinoma have a close relationship to the degree of malignancy of endometrium carcinoma,Contribute greatly to prognosis and can direct instruct postoperative therapy.
出处
《社区医学杂志》
2007年第04S期1-2,共2页
Journal Of Community Medicine
