摘要
目的：观察草酸铂联合亚叶酸钙、氟脲嘧啶治疗晚期胃癌的临床疗效和不良反应。方法草酸铂85MG／M2静脉滴注2小时，第1天，亚叶酸钙200MG／M2静滴2小时，第1-2天，氟脲嘧啶600MG／M2 IV、900MG／M2 CIV第1-2天，每2周重复。结果53例患者中CR3例、PR11例、SD5例、PD8例，总有效率CR＋PR14例（51．85％）。毒性反应主要为外周神经损害、恶心和呕吐、手足综合征。结论草酸铂联合亚叶酸钙、氟脲嘧啶治疗晚期胃癌的临床疗效好、毒性反应可以耐受。
Objective： To evaluate the activity and adverse of Oxaliplatin and Leucovorin / 5Fu in management of advanced gastric carcinoma. Methods： Oxaliplatin was administered as a 2-hour infusion at a 85MG/M2 on day 1; Leucovorin as a 2-hour infusion at a 200MG/M2 on day 1-2 and 5Fu at a dose 600MG/M2 IV and 900MG/M2 22-hour consecutive infusionon day 1-2 every 14 days. Results： Fifty-three patients were evaluable for response. CR3, PR11, SD5, PDS, and the overall response rate was14/53 （51.85%） .The major toxicity and side effects were peripheral newropathy,hand-foot syndrome,nausea and vomiting and at the same time they were acceptable. Conslusion： Oxaliplatin and Leucovorin / 5Fu is a effective regimen for patients of advanced gastric carcinoma.
出处
《医药世界》
2007年第3期54-55,共2页
Medicine World
