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盆底器官脱垂患者阴道Ⅰ型胶原及代谢的变化 被引量:4

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摘要 目的探讨盆底器官脱垂(pelvic organ prolapse,POP)患者阴道前壁筋膜组织中Ⅰ型胶原含量、合成代谢产物Ⅰ型前胶原羧基末端前肽(Carboxyterminal propetide of typeⅠprocollagen,PICP)及降解代谢产物Ⅰ型胶原交联羧基末端肽(Carboxyterminal telopeptide of typeⅠcollagen,ICTP)的变化。方法选择30例POP患者(POP组)及31例无SUI和POP的子宫肌瘤患者(对照组),术中行阴道前壁筋膜组织检查(活检),用酶联免疫吸附试验(ELISA)方法测量其Ⅰ型胶原、PICP、ICTP的含量。结果与对照组比较,POP组患者阴道前壁筋膜组织Ⅰ型胶原量明显减少,ICTP较对照组明显增加(P<0.05),PICP含量较对照组稍高,但差异无显著性(P>0.05)。结论POP患者盆底筋膜组织Ⅰ型胶原降解代谢增加,致其含量降低,对盆底支持力产生负面影响,可能是POP发病的重要原因之一。
出处 《广东医学》 CAS CSCD 北大核心 2007年第4期551-553,共3页 Guangdong Medical Journal
基金 福建省科技计划基金资助项目(编号:2003Y016)
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参考文献10

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