摘要
目的:了解阿奇霉素致儿童及青少年不良反应的数量、类型、分布和特点。方法:检索维普中文科技期刊数据库1995年～2006年关于阿奇霉素不良反应的文献,筛选收集16岁以下(含16岁)青少年及儿童不良反应的案例报告,统计各病例的性别、年龄、给药方法、临床表现、不良反应出现时间和转归等,并进行总结分析。结果:不良反应以6岁以下学龄前儿童为主,占60%以上,不良反应出现时间较短,2h内出现者占一半以上,类型及临床表现呈多样化。结论:对阿奇霉素在儿科的临床应用要给予高度重视,以保障儿童用药安全。
Objective： To learn the general pattern and characteristics of the ADRs associated with azithromycin to guide rational drug use. Methods： ADRs of azithromycin in 36 cases, reported in domestic medical journals during 1995-2006, were collected and analyzed. Results： ADRs of azithromycin often occurred in preschool children. The onset of ADRs was usually within 120 min after administration. ADRs could involve multiple organs and systems, and clinical manifestations and typos were various. Conclusions： Clinical physicians and pharmacists should pay more attention to the ADRs of azithromycin to assure rational drug use in children and adolescents.
出处
《儿科药学杂志》
CAS
2007年第2期37-38,40,共3页
Journal of Pediatric Pharmacy
关键词
药物不良反应
阿奇霉素
文献分析
儿童
Adverse drug reaction
Azithromycin
Literature analysis
Children
