摘要
目的探讨血浆M2-丙酮酸激酶(M2-PK)含量变化与胃癌发生的关系及M2-PK对胃癌的诊断价值。方法采用ELISA法检测55例正常人、50例胃癌患者、45例急慢性胃炎以及42例胃良性肿瘤患者血浆M2-PK和血清癌抗原199(CA199)含量,进行比较。结果胃癌组血浆M2-PK和血清CA199含量及阳性率明显高于对照组、急慢性胃炎组及胃良性肿瘤组(P<0.01);胃癌组血浆M2-PK和血清CA199含量比较差异无显著性(P>0.05)阳性率比较差异有显著性(P<0.01);正常对照组、急慢性胃炎组及胃良性肿瘤组,血浆M2-PK、血清CA199含量及阳性率组间比较差异均无显著性(P>0.05)。结论M2-PK是检测胃癌较为敏感的肿瘤标志物。M2-PK的敏感性高于CA199,具有广泛的临床应用价值。
[Objectve] To explore the relationship between the change of M2-PK level in plasm with the occurrence of gastric cancer and the diagnostic value for gastric cancer. [Methods] Plasm M2-PK and serum CA19-9 level were determined by using ELISA method in 55 normal persons, 50 patients with gastric cancer, 45 patients with acute gastritis or chronic gastritis and 42 patients with gastric beign tumors. [Result] The plasm M2-PK and serum CA19-9 level and positive rate in gastric cancer group were significantly higher than that in normal control group, acute gastritis of chronic gastritis group and gastric benign tumor group （P 〈0.01）. Significant difference of plasm M2-PK and serum CA19-9 level in gastric cancer group did not exist （P 〉0.05）, but the comparison of positive rate showed obvious difference （P 〈0.01）. The comparison of plasm M2-PK and serum CA19-9 level and positive rate among normal control group, acute gastritis or chronic gastritis group and gastric benign tumor group did not show significant difference （P 〉0.05）. [Conclusion] M2-PK had significantly higher sensitivity than CA19-9. It was considered to be better sensitive tumor marker, and had widespread clinical practice value.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2007年第6期722-724,共3页
China Journal of Modern Medicine
