摘要
目的:评价硼酸的体内雌激素样效应。方法:40只SD大鼠行双侧去卵巢后,随机分为5组,阴性对照组(蒸馏水),低、中、高剂量硼酸组(4mg/kg、25mg/kg及75mg/kg)及阳性对照组(0.10mg/kg雌二醇),连续给药3d后处死大鼠,测定子宫脏器系数及血清总雌二醇水平。结果:阳性对照组子宫脏器系数及血清雌二醇水平均高于阴性对照组(P均<0.05)。高剂量硼酸组大鼠子宫脏器系数高于阴性对照组(P<0.05);硼酸各剂量组血清雌二醇水平与阴性对照组相比,差异均无统计学意义(P均>0.05)。结论:硼酸能够诱导去卵巢大鼠子宫增重,具有雌激素样效应。
Aim： To evaluate the potential estrogenic effect of boric acid in vivo. Methods：A total of 40 rats without ovary were randomly divided into 5 groups： negative control group （distilled water） , low-, mid-, and high-dose boric acid groups （4 mg/kg, 25 mg/kg, and 75 mg/kg boric acid） , and positive control group （0.10 mg/kg estradiol）. Boric acid was administered by gavage for 3 days. The weight of uterus of ovariectomized SD rats and concentration of estradiol in blood serum were measured. Results： The uterine organ coefficient and concentration of estradiol in blood serum were higher than those of positive control group （ P 〈 0.05 ）. Uterine organ coefficient significantly increased in the high-dose group, compared with control （P 〈 0.05 ）. Concentration of estradiol in blood serum had no statistically difference in groups of boric acid, compared with control （ P 〉 0.05 ）. Conclusion ： Boric acid could stimulate the growth of uterus of ovariectomized rats and has estrogenic effect.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2007年第2期332-334,共3页
Journal of Zhengzhou University(Medical Sciences)
