摘要
[目的]评价18F-FDG PET/CT显像在探测卵巢癌术后复发病灶中的应用价值。[方法]采用仪器为Siemens Biograph Sensation 16 PET/CT,43例卵巢癌术后患者禁食4～6h,静脉注射18F-FDG60min后进行PET/CT检查,采集方式为3D模式。PET/CT图像结果与血清CA125、B超及CT或MRI影像学资料进行比较。并与手术病理或临床随访结果比较判断其诊断的准确性。[结果]FDG PET/CT诊断卵巢癌复发的灵敏度、特异性和准确性分别为92.3%、100%和93.0%。血清CA125水平与FDG PET结果有一定相关性,33例CA125升高患者中31例PET显像阳性,10例CA125正常水平患者中仅有5例PET显像阳性。[结论]当常规影像学检查阴性或可疑时,PET/CT显像对卵巢癌复发的检测具有较高的灵敏度和准确性,特别术后患者CA125升高的情况下,FDG PET/CT有助于探测隐匿性复发或转移病灶,指导进一步的治疗。
[Purpose] To evaluate the value of integrated positron emission tomography（PET）and computed tomography（CT）for depiction of recurrence ovarian carcinoma after surgery.[Methods] The model of PET/CT scanner we used is Siemens Biograph Sensation 16.Forty-three women who had previously undergone surgery for ovarian cancer were included.The patients received 18F-FDG intravenously after fasting for 4 to 6 hours.3D whole body PET/CT scans were acquired 60 min after injection.PET/CT imaging results were compared with the results of serum CA125 levels and ultrasound,CT or MRI conventional imaging.PET/CT results were compared to histologic examination after surgery and clinical follow-up to determine the diagnostic accuracy of PET/CT in the evaluation of disease status.[Results]The overall sensitivity,specificity,accuracy of PET/CT were 92.3%,100%,93.0% respectively.There was a positive correlation between serum CA125 and positive result of FDG PET/CT.PET/CT could detect recurrent lesions in 31 of 33 patients in whom increased serum CA125 level.Among the 10 patients with serum CA125 in normal range,PET/CT correctly detected recurretn foci in 5 patients.[Conclusion]PET/CT depicts recurrent ovarian carciooma with a high sensitivity and accuracy when conventional imaging is inconclusive or negative,especially in patients with increased CA125 levels.FDG PET/CT image can help to detect occult metastasis and direct further treatment to the precise site of tumor recurrence.
出处
《中国肿瘤》
CAS
2007年第3期187-189,共3页
China Cancer
关键词
卵巢肿瘤
复发
转移
PET/CT
ovarian neoplasms
recurrence
neoplasm metastasis
PET/CT
