摘要
目的:探讨益气通阳化痰法中药复方对高脂血症及动脉粥样硬化(AS)的防治作用及其机制。方法:喂饲高脂饮食制备高脂血症及AS动物模型。32只大耳白兔被随机分为正常组、模型组(高脂组)、活血化瘀方治疗组(活血组)和益气通阳化痰方治疗组(化痰组),每组8只。于实验前、实验第6周末和第12周末测定血脂水平、血小板聚集率和黏附率、丙二醛(MDA)、内皮素-1(ET-1)、一氧化氮(NO)以及主动脉内膜脂质斑块面积比与斑块厚度。结果:喂饲高脂饮食后,高脂组血脂、血小板黏附率和聚集率、MDA、ET-1、内膜脂质斑块面积比与斑块厚度均显著增高,血清NO3-/NO2-含量显著降低。与高脂组比较,化痰组与活血组血脂、血小板黏附率和聚集率、MDA、ET-1均显著降低,NO3-/NO2-含量显著升高,且化痰组调脂作用,降低MDA、ET-1含量,升高NO3-/NO2-含量均明显优于活血组;但化痰组与活血组间血小板黏附率和聚集率差异均无显著性;化痰组的内膜脂质斑块面积比与斑块厚度较活血组小(P均<0.05)。内膜脂质斑块面积比与TC、MDA、血小板黏附率、ET-1和NO具有良好的相关性(P均<0.05)。结论:益气通阳化痰方及活血化瘀方通过治疗高脂血症、抗氧化、改善血小板功能、调节血管活性物质等作用防治AS,以益气通阳化痰方的作用更好。
Objective： To study the mechanism and effect of Chinese medicine Yiqi Tongyang Huatan prescription （益气通阳化痰方, YQTYHT ） on hyperlipidemia and atheroselerosis （AS）. Methods ： The rabbit＇s model was established by feeding the food containing high cholesterol, and 32 rabbits were randomly divided into four groups （each n= 8）： normal group, model group, Huoxue Huayu prescription treatment group （活血化瘀方, HXHY group） and YQTYHT treatment group （YQTYHT group）. Before the experiment, at the end of 6 th and 12, th weeks after the experiment, the following items were measured： blood lipids platelet aggregation rate, platelet adhesion rate, malondialdehyde （MDA）, endothelin - 1 （ET- 1）, nitric oxide （NO）, the ratio of the lipid plaque area and the thickness of the endothelial plaque. Results： After feeding the food containing high cholesterol, the blood lipids, platelet aggregation rate, platelet adhesion rate, MDA, ET - 1, the ratio of lipid plaque area and the thickness of plaque were elevated significantly, while serum NO3^-/NO2^- decreased significantly in model group. Compared with the model group, the blood lipids were lower in the two treatment groups, and the blood lipid regulating effect in YQTYHT group was significantly better than that in HXHY group. Platelet aggregation rate and platelet adhesion rate of YQTYHT group and HXHY group were lower than those in the model group, but the degree of lowering in YQTYHT group and HXHY group had no significant differences. The serum MDA of YQTYHT group and HXHY group was lower than that in model group, and the Lowering effect in YQTYHT group was better than that in HXHY group. YQTYHT group and HXHY group had a significant increase on the level of serum NO3^-/NO2^- and a decrease on the content of plasma ET - 1, furthermore, the effects in the former group were significantly better than those of the latter group. The area of atherosclerotic plaque coverage in aorta and the thickness of plaque of HXHY group were
出处
《中国中西医结合急救杂志》
CAS
2007年第2期83-87,共5页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
湖北省自然科学基金资助项目(97J066)
关键词
益气通阳化痰方
动脉粥样硬化
实验研究
Yiqi Tongyang Huatan prescription
atherosclerosis
experimental study
