摘要
将１００例癌痛和术后疼痛病人随机分为三组。Ｍ组４０例，硬膜外腔注入吗啡４ｍｇ；Ｔ组４０例，硬膜外腔注入曲马多５０ｍｍ；Ｓ组２０例，硬膜外腔注入５％高渗盐水５ｍｌ。观察结果，三种药物均能产生显著的镇痛效果，有效时间吗啡最长，平均为１８．６±８．３ｈ，曲马多其次，为１４．９±６．６ｈ，高渗盐水最短，为７．５±０．７ｈ。吗啡对血流动力学有明显的抑制性影响，收缩压，平均压和心率显著下降（Ｐ＜０．０５～０．０１）对呼吸有抑制作用，潮气量每分通气量明显下降（Ｐ＜０．０５）。曲马多只有轻度的循环抑制作用，但没有呼吸抑制作用。高渗盐水组未见明显的副作用。本组观察的用意在于针对不同的病情选用不同的药物，以达到足够长的镇痛效果，又尽量避免药物的副作用。
One hundred cases of cancer pain and post operative patients were randomly divided into tree groups.The M group,40 cases, were injected with 4mg morphine into epiduralspace;the T group,40 cases,were injected with 50mg tramadol epidurally;the S group,20 cases,were injected with 5ml of 5% saline.Satisfactory analgesic effect were observedin all 3 groups. The duration of analgeisa was longest in the M group,lasting for 18.6±8.3h,14.9±6.6h in the T group,and only 7.5±0.7h in the S group.Concerning the adverse effects, morphine produced a suppression of the hemodynamic parameters(a significant decrease of blood pressure and heart rate)and a lowering of the ventilation function(a significant decrease of fidal volume,and minute volume).Tramadol produced a mild circulatory depressive effect,without respiratory suppression.Hypertonic saline produced verylittle side effects.The results suggest that all the 3 drugs can be chosen for epidural analgesia, in order to obtain sufficently long duration and minimal adverse effects.
出处
《中国疼痛医学杂志》
CAS
CSCD
1996年第3期147-151,共5页
Chinese Journal of Pain Medicine
关键词
吗啡
曲马多
手术后
镇痛
硬膜外注药
Morphine
Tramadol
Hypertonic saline
Epidural analgesia
