摘要
目的探讨胃肠道肿瘤术后真菌感染的危险因素,为临床预防真菌感染提供理论依据。方法回顾性分析我院本专业组2006年1—6月间行胃肠道肿瘤手术患者116例的相关病史资料,对真菌感染的可能危险因素进行单因素和多因素lo- gistic回归分析。结果①116例中诊断为真菌感染的18例,共获46份培养阳性标本,真菌感染患者菌种以白念珠菌为主,占15/20,感染部位以肠道为主,占14/18;②胃肠道肿瘤手术后真菌感染与抗生素使用时间、术后禁食时间、低蛋白血症、术后高血糖、合并细菌感染有关,其中抗生素使用时间是独立相关因素(P＜0．05)。结论胃肠道肿瘤术后应规范使用抗生素、营养支持、适时开始肠内营养、控制血糖,从而有效预防真菌感染。
Objective To investigate the relevant risk factors for fungal infection following operation of the gastrointestinal neoplasm and offer supporting data for the prevention of fungal infection. Methods Medical records from 116 patients who underwent the operation of gastrointestinal neoplasm in the special group of this hospital from January 2006 to June 2006 were retrospectively reviewed on the relevant risk factors by univariate and multivariate Logistic regression analysis. Results Of the 116 patients reviewed, 18 had fungal infection. Forty-six samples were positive for fungal pathogen. The most frequently isolated fungal strain was Candida albicans （15/20） and the most common infection site was gastrointestinal tract （]4/18）. Fungal infection after the operation of gastrointestinal neoplasm was significantly relevant with the duration of antibiotic use, duration of post-operative fasting, low serum albumin, high blood glucose and complication of bacterial infection. The duration of antibiotic use was a significantly independent risk factor. Conclusions Reasonable antibiotic use, nutritional support, early enteral nutrition and control of blood glucose should be taken into account after the operation of gastrointestinal neoplasm in order to prevent fungal infections.
出处
《中国感染与化疗杂志》
CAS
2007年第1期25-27,共3页
Chinese Journal of Infection and Chemotherapy
关键词
胃肠道肿瘤
真菌感染
危险因素
Gastrointestinal neoplasm
Fungal infection
Risk factor
