摘要
目的探讨活化CD4+淋巴细胞及HBeAg与慢性乙型肝炎肝脏损伤及纤维化的关系。方法检测58例慢性乙型肝炎患者和18例HBcAb阳性者CD4抗原和HLA-DR抗原双阳性淋巴细胞,血小板(Plt)数及血清丙氨酸氨基转移酶(ALT)和天门冬氨酸氨基转移酶(AST)活度,计算AST/Plt比值。结果既往感染患者、HBeAg阴性及阳性慢性乙肝患者活化CD4+细胞数量明显低于对照组(P<0.05),且呈显著递减(P<0.05),HBeAg阴性及阳性者AST,ALT以及AST/Plt值明显高于对照组(P<0.02)和既往感染组(P<0.02),且HBeAg阳性患者明显高于阴性患者(P<0.05),此2组活化CD4+细胞与ALT,AST和AST/Plt呈明显负相关(P<0.05)。结论活化Th细胞降低可以作为慢性乙肝患者预测肝脏损伤进展的指标,HBeAg可以辅助评价肝损伤和纤维化的发展程度。
Objective It is to discuss the relationship between activation CD4^＋ lymphocyte and HBeAg with hepatic injury and fibrosis in chronic type B hepatitis. Methods CD4 antigen and HLA - DR antigen double masculine lymphocyte, Pit count, ALT and AST activity in 58 cases of chronic type B hepatitis and 18 cases of HBcAb （ ＋ ） were detected. AST/Plt ratio was computed. Results Activation CD4^＋ lymphocyte quantity in already infection, HBeAg （ - ） and HBeAg （ ＋ ） of chronic type B hepatitis patients were obviously lower than that in control group （P〈 0.05 ） and were significantly decrement （P〈0.05）, AST, ALT and AST/Plt ratio in HBeAg （ - ） and HBeAg （ ＋ ） patients were obviously higher than that in control group （P〈0.02） and already infection group （P〈0.02）, and that in HBeAg （ ＋ ） patients were obviously higher than that in HBeAg （ - ） patients （P 〈 0.05）. Activation CD4^＋ lymphocyte, AST, ALT and AST/Plt ratio in the two groups were obviously negative correlation （P 〈 0.05 ）. Conclusion Activation Th cell lowered can be taken as the index of chronic type B hepatitis patients predicting hepatic injury progression. HBeAg can assist to evaluate the development degree of hepatic injury and fibrosis.
出处
《现代中西医结合杂志》
CAS
2007年第11期1452-1453,1457,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
