摘要
目的：观察阿扎司琼对术后曲马多静脉自控镇痛疗效的影响。方法：90例择期上腹部手术且接受术后曲马多静脉自控镇痛病人，ASAⅠ级～Ⅱ级，随机分为3组，每组30例，C组，生理盐水对照组，B组，胃复安组；A组，阿扎司琼组。观察各纽术后4小时、8小时、12小时、24小时的视觉模拟评分（VAS）、曲马多用量及镇静评分等不良反应。结果：术后4小时、8小时A组VAS高于C组、B组（P〈0．05）；术后8小时、12小时、24小时，A组的曲马多累计用量高于C、B组（P〈0．05）。但A组对恶心呕吐的防治作用优于C、B组（P〈0．01，P〈0．05）。3组间镇静评分差异无显著意义。结论：阿扎司琼会降低术后曲马多静脉白控镇痛的效果。
Objective： To evaluate the analgesic effects of tramadol in surgical patients receiving patient-controlled intravenous analgesia（PCIA） with concurrent administration of azastron. Methods： Ninty patients（ASA Ⅰ -Ⅱ ）undergoing selective upper abdominal Surgery were randomly divided into three groups with 30 cases each. Group A was given azasetron 10mg, tramadol 1500 mg and 0.9% NaCl diluted to 100ml, group B metoclopramide 20 mg, tramadol 1500 mg and 0.9% NaCl diluted to 100ml, and group C tramadol 1500 mg plus 0.9% NaCl diluted to 100ml, and group C tramadol 1500mg plus 0.9% NaCl diluted to 100ml. Postoperative pain nausea and vomiting, sedation, other side effects and the dosage of tramadol were observed at 4, 8, 12 and 24h during postoperative analgesia. Results： The VAS scores in group A were higher than those in group C and group B at 4h and 8h after operation（P〈0.05）. Meanwhile, the accumulative total amount of tramadol in group A was more than that in group C and group B at 8, 12 and 24h after operation（P〈0.05）. The incidence of nausea and vomiting in group A was obviously lower than that in group C and group B postoperatively（P〈0.01, P〈0.05）. Sedation scores were similar among three groups. Conclusion： Azasetron can inhibit the analgesic effects of tramadol during PCIA.
出处
《中国伤残医学》
2007年第1期17-19,共3页
Chinese Journal of Trauma and Disability Medicine
关键词
阿扎司琼
病人自控镇痛
曲马多
Azasetron
Patient-controlled analgesia
Tramadol
