摘要
PPAR与2型糖尿病存在密切关系,该受体已成为抗2型糖尿病的主要靶点。本文以PPAR三种亚型PPARα、PPARγ和PPARβ/δ为靶点的高通量筛选模型,对苦瓜多糖进行活性筛选。筛选结果表明苦瓜多糖对PPARδ和PPARγ具有较强的激活效果,其激活倍数分别达1.995、1.689。苦瓜多糖是一种潜在的降糖、降脂的活性成分。
It is found that type 2 diabetes millitus is closely related to PPAR which is now employed as main target anti-diabetes to treatment of type 2 diabetes millitus. Momordica charantia L. is a traditional Chinese medical herb. Recent research showed that there were some hypoglycemic active components in Momordica charantin L. Screening PPARα, β/δ, γ antagonits from Momordica Charantia extracts by HTS was studied in this paper. Results showed that MCP（Momordica charantia polysac, charides） was an antagonist of PPARγ and PPARβ/5 and the activiation times are 1.689 and 1.995, respectively. MCP can be a potential anti-diabetic agent.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2007年第2期313-316,共4页
Food Science
关键词
PPAR
HTS
苦瓜
2型糖尿病
PPAR（peroxisome proliferator-activated receptor）
HTS（high throughput screening）
Momordica charantia L.
type 2 diabetes mellitus
