摘要
蛋白激酶C(PKC)是一个广泛分布在真核细胞中的丝氨酸/苏氨酸蛋白激酶家族。它在卵母细胞的生发泡破裂(GVBD)、染色体凝集、MⅠ期纺锤体组装和第一极体排放等过程中起着重要的调节作用。PKC的活性变化调节着GVBD的发生,GVBD标志着第1次减数分裂的启动。PKC活性在卵母细胞成熟过程中逐渐升高,在第1次减数分裂中/后期转变时活性下降,使卵母细胞得以释放出第一极体,至此卵母细胞完成第1次减数分裂进入第2次减数分裂。作者就PKC在卵母细胞第1次减数分裂成熟过程中的作用综述如下。
Protein kinase C （PKC） is a family of Ser/Thr protein kinases commonly distributed in eukaryotic cells. It plays a pivotal role in the regulation of germinal vesicle breakdown （GVBD）, chromatin condensation, spindle assembly and extrusion of the first polar body. Activity of PKC regulates GVBD, which characterizes the reinitiation of Meiosis Ⅰ . The activity of PKC rises gradually during the early maturation process and descends during the shift from metaphase to anaphase, which induces the extrusion of the first polar body and characterizes the finish of Meiosis Ⅰ and the transition to Meiosis Ⅱ . Here in this article, the recent advances of research in PKC in the process of Meiosis I during mammalian oocyte maturation is reviewed.
出处
《中国畜牧兽医》
CAS
2007年第1期68-71,共4页
China Animal Husbandry & Veterinary Medicine
