摘要
观察体外循环(CPB)时硬膜外阻滞加全麻对应激反应的影响。21例体外循环心脏直视手术的患者分成两组,对照组以大剂量芬太尼静脉全麻辅以安氟醚吸入;试验组以硬膜外阻滞辅以安氟醚吸入。结果显示:在CPB中,对照组的去甲肾上腺素和肾上腺素血浆浓度明显高于试验组(P<0.01,P<0.05);在CPB结束时和手术结束时,对照组的去甲肾上腺素血浆浓度仍高于试验组(P<0.05)。为控制血压,对照组硝普钠用量明显大于试验组。提示全麻加硬膜外阻滞,可更大程度地抑制应激反应,从而稳定了血液动力学。
Effects of epidural block on stress response during eardiopulmonary bypass were studied. Twenty patients, undergoing open heart surgery with cardiopulmonary bypass, were randomly divided into two groups:the control group with intravenous high-dose fentanyl and enflurane inhalation (1%-1.5%);the tested group with epidural block and enflurane inhalation (0.5%-1%). The plasma norepinephine (NE) and epinephrine (E) concentrations were higher in group control than those in tested group during and after CPB,even at the end of operation (P<0.05 or 0.01). The total required dosage of sodium nitroprusside increased markedly compared with that in tested group (P<0.05). In conclusion,epidural block combined with general anesthesia produces better hemodynamic stability by reducing the release of NE and E.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1996年第10期492-494,共3页
Chinese Journal of Anesthesiology
关键词
体外循环
硬膜外阻滞
应激反应
全麻醉
Cardiopulmonary bypass Epidural block General anesthesia Stress response
