摘要
目的:探讨胃癌抗原(MG-7)、癌胚抗原(CEA)、糖类相关抗原(CA19-9、CA72-4)对胃癌的辅助诊断及预后判断的价值。方法:对60名健康体检者、60例胃炎组患者、56例其他癌肿患者组及60例胃癌患者术前及术后3个月的血清标本用酶联免疫吸附试验或化学发光法进行4种标志物的检测。结果:在胃癌术前组,MG-7为(7．0±5．1)U/ml,CEA为(76．6±264．4)μg/L,CA19-9为(84．8±187．7)U/ml,CA72-4为(47．6±88．6)U/ml,与健康体检组、胃炎组、其他癌肿患者组相比,有不同程度的升高;这4种肿瘤标志物联合检测较其中任何一个标志物单项检测的灵敏度均有较大的提高;分析胃癌患者术后3个月4种肿瘤标志物的含量变化,发现均较术前明显降低。结论:MG-7、CEA、CA19-9和CA72-4的联合检测可提高对胃癌辅助诊断的灵敏度;动态观察胃癌患者血清中这4种肿瘤标志物含量的变化,对胃癌的辅助诊断、疗效评估均有重要意义。
Objective To explore the clinical significance of the combined detection of tumor markers MG-7, CEA, CA19-9 and CA72-4 in the diagnosis and the prognostic judgment of gastric carcinoma. Methods The four tumor markers were detected by ELISA or chemiluminescent methods in 60 healthy controls, 60 patients with gastritis, 56 patients with cancers out of stomach and 60 patients with gastric carcinoma before the operation and in three months after the radical operation. Results The serum levels of MG-7, CEA, CA19-9 and CA72-4 in the patients with gastric carcinoma before operation were （7.0±5.1） U/ml, （76.6±264.4） μg/L, （84.8±187.7） U/ml and （47.6±88.6） U/ml, respectively, which were higher than those in either of the other groups. The combined detection of the four tumor markers had higher sensitivity than the single detection of the each tumor marker. The serum levels of MG-7, CEA, CA19-9 and CA72-4 in the patients with gastric carcinoma in three months after the radical operation were obviously lower than those before the operation. Conclusions The combined detection of MG-7, CEA, CA19-9 and CA72-4 could improve the sensitivity of diagnosis in gastrie carcinoma. Changes of the serum MG-7, CEA, CA19-9 and CA72-4 levels have significant value in the diagnosis and the evaluation of therapeutic effect.
出处
《诊断学理论与实践》
2007年第1期43-45,共3页
Journal of Diagnostics Concepts & Practice
