摘要
目的探讨支气管动脉导管化疗（简称动脉化疗）对改善老年人晚期肺癌的疗效及生存期。方法对不能手术的老年人中心型肺癌２０例，用环磷酰胺、阿霉素（或表阿霉素）及顺铂进行支气管动脉灌注２～４次治疗，加用放疗或放疗后复发患者加动脉化疗。结果治疗有效率６０％，平均生存期１６．２个月，中位生存期１２．０个月。主要副作用是骨髓抑制，特别是粒细胞减少，与常规静脉化疗的副作用相类似，未见其它严重的不良反应。结论动脉化疗加放疗能改善老年人晚期肺癌的疗效及生存期，特别是非小细胞肺癌，其不良反应是可耐受的。
Objective To observe the efficacy and the survival of aged patients with inoperable lung cancer by chemotherapy bronchial artery via. Methods To 20 cases of central type lung cancer each patient was given two to four times of intra-arterial injection of cyclophosphamide, adriamycin(or epirubicin) and cisplatin bronchial artery via, combined with radiotherapy. Results The response rate was 60%. The mean survival time of patients was 16. 2 months and the median survival 12months. The main side effect was myelosuppression, especially granulocytopenia , which was similar to that of conventional intravenous chemotherapy. No other severe adverse effect was seen. Conclusiou The results showed that bronchial intraarterial chemotherapy combined with radiotherapy can improve the response rate and survival time of aged patients with inoperable lung cancer, especially nonsmall cell cancer. The adverse effect was tolerable.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
1996年第4期196-198,共3页
Chinese Journal of Geriatrics
关键词
肺肿瘤
药物疗法
支气管动脉
输液
动脉内
lung neoplasms bronchial arteries infusions ,intra-arterial
