摘要
目的探讨环氧化酶-2(COX-2)蛋白在鼻咽癌组织中的表达及其临床意义。方法应用免疫组织化学方法检测45例鼻咽癌组织及20例鼻咽黏膜不典型增生组织中COX-2的表达。结果鼻咽癌组织中COX-2蛋白阳性表达率为71.1%(32/45),鼻咽黏膜不典型增生中COX-2蛋白阳性表达率为10.0%(2/20),两者比较差异具有统计学意义(P<0.001)。结论COX-2蛋白在鼻咽癌组织中表达增高,表明COX-2可能在鼻咽癌的发生发展中起重要的作用。
Objective To explore the expression of cyclooxygenase-2 （COX-2） in nasopharyngeal carcinoma （NPC） and its clinical significance. Methods The expression of COX-2 was detected by immunohistochemieal method in specimens from 45 NPC patients and 20 cases of nasopharyngeal atypical hyperplasia. Results The positive rates of COX-2 in NPC patients and atypical hyperplasia patients were 71.1%（32/45）, 10.0%（2/20） respectively and the difference was statistically significant （ P 〈0. 001）. Conclusion The expression of COX-2 is enhanced in NPC tissue, which indicates COX-2 may play an important role in the pathogenesis and development of this tumor.
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
2007年第1期25-27,共3页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
关键词
鼻咽肿瘤
癌
鳞状细胞
免疫组织化学
环氧化合物
Nasopharyngeal neoplasm
Carcinoma, squarnous cell
Immunohistochernistry
Epoxy compounds
