摘要
目的:探讨高菌量病人在完成2年联合化疗(MDT)后采用强化治疗的疗效和安全性。方法:把初始细菌指数(B I)≥4的多菌型麻风病70例在其完成MDT后分为治疗组和对照组,治疗组用ROM(利福平+氧氟沙星+米诺环素)方案继续治疗;对照组口服维生素和钙片。两组病例分别在治疗前后进行临床和细菌指数的比较和评价。结果:在治疗结束时两组的治愈率比较差异无统计学意义(P>0.05);总有效率比较差异有统计学意义(P<0.01);两组的细菌阴转率比较差异无统计学意义,但治疗组细菌指数下降程度大于对照组(P<0.01)。结论:ROM对高菌量多菌型麻风有较好的疗效和安全性,而且依从性好和易于监服,可推荐用于强化治疗。
Objective：To evaluate the therapeutic effects and safety of ROM （Rifampin plus Ofloxacin plus Minocycline） on muhibacillary leprosy patients with high bacterial loads after a 2- year course of muhidrug therapy （MDT）. Methods： 70 patients with initial bacterial index （BI）≥ 4 were allocated to ROM group and control group respectively by the end of MDT. Results： The accumulative cure rates were 60. 0% in ROM group and 42.27% in control respectively. The difference between two groups was not statistically significant （ P 〉 0. 05 ）, but their total effective rates had statistical significant （ P 〈 0. 05 ）. and the BI of the ROM group declined greater than that of the control（ P 〈 0. 01 ）. Conclusion： ROM was effective and safe in treatment of muhibacillary leprosy patients with high bacterial loads, it can be used to intensive treatment of muhibacillary leprosy with high bacterial loads due to easily to be complied with and a fully supervisable monthly administered.
出处
《岭南皮肤性病科杂志》
2007年第1期7-9,共3页
Southern China Journal of Dermato-Venereology
基金
广东省医学科研课题(项目编号:A2003133)
关键词
高菌量
多菌型麻风
强化治疗
ROM方案
High bacterial loads
Muhibacillary leprosy
Intensive treatment
ROM regimen
