摘要
研究了以3,4-二氯硝基苯为原料通过卤素交换氟化合成3-氯-4-氟硝基苯的反应。结果表明,微波加热条件下反应速率是常规加热的3～12倍,收率和选择性也都有提高。金属Lewis酸AlCl3和SbCl3用作本反应的催化剂可以取得良好的效果,其中SbCl3效果最好,用于400W微波加热反应10min可得到97.0%的收率。
3-Chloro-4-fluoronitrobenzene was prepared fluorination. The reaction rate under microwave heating from 3,4-dichloronitrobenzene through halogen-exchange was 3-12 times higher than that under conventional heating, and the yield and selectivity increased as well. AlCl3 and SbCl3 were applied in this reaction to give excellent results. The best result was obtained in a high yield of 97.0% when 400 W microwaves were used for 10 min.
出处
《精细化工中间体》
CAS
2007年第1期30-33,共4页
Fine Chemical Intermediates
