摘要
辅酶Q10是一种具有重要生理和药理作用的生命活性物质,用途十分广泛。特别是近年来随着对其生理和药理作用认识的不断深入,辅酶Q10已经成为了一种重要的药品和保健品。笔者根据半个世纪以来有关辅酶Q10化学合成的各种文献报道,对辅酶Q10现有的各种化学合成路线及其工艺优劣进行了介绍和比较,重点介绍了从烟草中提取天然茄尼醇为原料的半化学合成辅酶Q10方法,并阐明了化学合成辅酶Q10的关键因素和发展方向。
Coenzyme Q10 is a vital human nutrient substance with extensive uses. It has very important physiological and pharmacological activities, Especially with a deeper knowledge of its physiological and pharmacological activities, coenzyme Q10 has became an important kind of pharmaceutical and health-care product. In this paper, various synthetic methods of coenzyme Q10 appeared in about half a century were reviewed with emphasis on the semi-chemosynthetic methods using natural solanesol extracted from tobacco as starting material. The key factors and development direction of coenzyme Q10 chemosynthesis were illustrated in this paper as well.
出处
《精细化工中间体》
CAS
2007年第1期9-14,共6页
Fine Chemical Intermediates
基金
湖南省科技厅科技攻关资助项目(04FJ4116)
