摘要
目的:观察氟比洛芬酯脂微球载体注射液(商品名凯纷)治疗癌痛的疗效和副作用。方法:38例未使用阿片类药物的中重度癌性疼痛患者每天静脉注射50mg/5ml氟比洛芬酯脂微球载体注射液,分别就其疗效、生活质量改善情况以及不良反应等方面进行评价。结果:氟比洛芬酯脂微球载体注射液治疗中重度癌痛的有效率为71.05%,生活质量改善情况治疗前后有显著差异(P<0.05)。但未见一般非甾体类药物常见腹痛、消化道出血等副作用;也未见便秘、恶心、呕吐、嗜睡等阿片类药物常见不良反应。结论:氟比洛芬酯脂微球载体注射液治疗中重度癌痛疗效可靠,生活质量可得到改善,但氟比洛芬酯脂微球载体注射液不良反应发生率较低,可部分作为临床候选药品或口服吗啡替代药。
Objective: To observe the analgesic effect of flurbiprofen axetil injection in treatment of middle and severe pain in cancer patients. Method: The study was conducted in 38 case cancer patients.They were allocated to receive 50mg/5ml/day of flurhiprofen axetil injection for 2 weeks.Results: A total effective rate of 71.05% were achieved.In the study we did not observe the severe adverse reaction of flurbiprofen axetil injection. Conclusion: Flurbiprofen axetil injection was effective for middle and sever pain in cancer, its side effect were slight.
出处
《福州总医院学报》
2006年第3期142-143,共2页
Journal of Fuzhou General Hospital
关键词
氟比洛芬酯
脂微球
癌症疼痛
镇痛作用
Flurbiprofen axetil injection Lipid microspheres Carcinous pain Analgsic effect