摘要
目的:探索TIP30蛋白对预测非小细胞肺癌患者复发及存活的价值。方法:利用NSCLC组织标本的蜡块进行免疫组织化学染色,回顾性分析与复发、转移及存活的关系。结果:肺脏原发病灶中TIP30蛋白的低表达与临床分期、患者5年存活率、总体复发率及转移有关,而与组织类型和肿瘤细胞病理学分化程度高低无关。结论:TIP30蛋白可以作为一个预测NSCLC肺癌患者术后复发或转移的分子标志物,为临床上预测肺癌的复发或转移提供新的线索。
Objective： To probe into the value of a newly found tumor suppressor gene TIP30 as a molecular marker for the prediction of relapse or metastasis of lung cancer patients. Method： In our present study, immunohistochemical analyses of a retrospective database of pathologic specimens were used to demonstrate the expression of TIP30 protein in NSCLC. Results： The low expression of TIP30 protein in NSCLC tumor tissue was statistically significant in the clinical stage, the relapse or metastasis or 5 year diseasefree survival rate, whereas low levels of TIP30 expression did not relate to histologic type and histologic differentiation.Conclusion： TIP30 protein may be used as a molecular marker to identify and predict the re.lapse or metastasis of NSCLC, and may provide a new clue for the clinical doctor to evaluate the prognosis of patients suffered with NSCLC.
出处
《福州总医院学报》
2006年第3期134-136,共3页
Journal of Fuzhou General Hospital
