TIP30基因在肝癌组织中的表达及意义

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摘要 CC3基因是1997年shtivelman用RNA差异显示技术比较高转移性小细胞肺癌及低转移性小细胞肺癌细胞系时首先发现的一种与肿瘤转移有关的基因。1998年肖华等亦发现一种分子量为30kd的转录共分子，可特异性地提高HIV-1增殖调节蛋白Tat的转录，并命名为TIP30（Tatinteractingprotein30）。序列分析发现与CC3为同一蛋白。此基因的1．6kb的RNA转录产物在人的心、胎盘、肺、肝、肾、胰腺等正常组织和某些肿瘤细胞系中广泛存在。近年来的研究表明。TIP30基因具有抑制肿瘤转移、促进肿瘤细胞凋亡、抑制肿瘤血管形成等作用。目前TIP30蛋白在肝癌组织中的表达、在肝癌发生发展过程中可能存在的作用未见文献报道。

作者张霞陈曦陈樟树欧阳学农

机构地区福州总医院肿瘤科

出处《福州总医院学报》 2006年第4期200-201,共2页 Journal of Fuzhou General Hospital

关键词 TIP30基因肝癌组织抑制肿瘤转移肺癌细胞系小细胞肺癌差异显示技术转录产物肿瘤细胞凋亡

分类号 R735.7 [医药卫生—肿瘤]

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共引文献162

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TIP30基因在肝癌组织中的表达及意义

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