摘要
目的:研制盐酸格拉司琼口腔崩解片,并对其进行质量评价。方法:以崩解时间和口感为主要指标,优化处方和工艺,采用全粉末直接压片法制备盐酸格拉司琼口腔崩解片。结果:结果表明所制备的盐酸格拉司琼口腔崩解片崩解时间在35 s以内,口感良好,其他指标均符合有关规定。结论:所筛选的处方合理,制备工艺简便,适宜于大生产,质量可控。
Objective： Research to manufacture the granisetron hydrochloride orally disintegrating tablets and to evaluate it＇s quality. Methods： Using disintegration time and oral feeling as the main evaluation parameter , grading-up prescription and product craft, the tablets were prepared by powder direct eompression. Results： The dissolution time of Granisetron Hydrochloride disintegrating tablet in oral cavity was 35 s and had a good oral feeling, the other parameter all meets the provision. Conclusion： This prescription is reasonable and product craft is simple , it can be used in industrial product and quality controllable.
出处
《河南大学学报（医学版）》
CAS
2006年第4期24-26,共3页
Journal of Henan University:Medical Science
关键词
盐酸格拉司琼
口腔崩解片
微晶纤维素
交联聚维酮
崩解时间
granisetron hydrochloride
orally disintegrating tablets
microcrystaline cellulose
cross - linked polyvinylpyrrolidone
disintegration time
