摘要
目的观察他汀类降脂药洛伐他汀对冠心病慢性心力衰竭预后的影响。方法冠心病慢性心力衰竭患者122例，随机分为洛伐他汀组（60例），对照组（62例）。所有心力衰竭患者均常规治疗，治疗组加用洛伐他汀20mg，每晚1次。治疗2个月后复查血脂常规、C反应蛋白（C-RP）、左室射血分数（LVEF）。观察所有患者的住院次数、总住院日数、病死率。结果洛伐他汀治组与对照组比较，治疗2个月后，血清总胆固醇（TC），低密度脂蛋白胆固醇（LDL-C）、C-RP均有不同程度的降低，LVEF则有明显提高。治疗组和对照组比较，住院次数和总住院日数减少，但差异无统计学意义（P〉0．05）；病死率明显降低（P〈0．01）。结论洛伐他汀治疗冠心病慢性心力衰竭能够改善患者的预后。
Objective To observe the effects of lovastatin on the prognosis of patients with chronic heart failure with coronary heart disease. Methods From December 2003 to December 2005,122 cases were divided randomly into tow groups： the treatment group（ n = 60） ,who received lovastatin 20mg qn,and the control group（ n = 62）. All pati, ents with heart failure were treated by conventional therapy. Results Compared with the control group,the total cholesterol（TC）, LDL-C, C-RP of the patients in the treatment group were all degraded to different degrees and the LVEF was elevated obviously. The frequency of hospitalization and the time were lower than that in the control group but was not significantly different;The death rate was significantly lower than that in the control group（ P 〈 0.01）. Conclusion The prognosis of patients with chronic heart failure with coronary heart disease can be improved by lovastatin.
出处
《中国基层医药》
CAS
2007年第1期80-81,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
心力衰竭
充血性
洛伐他汀
预后
Heart failure, congestive
Lovastatin
Prognosis
