摘要
目的:建立随意皮瓣放射损伤动物模型并对其进行病理学研究。方法:60只普通级Wistar大鼠被随机分成5组,进行随意皮瓣动物模型建立和放射损伤模型的建立。对其进行临床观察,并于放疗后第28d分别进行明胶墨汁灌注和病理学检查。结果:成功建立随意皮瓣放射损伤动物模型,并验证随局部放射剂量增加,皮瓣内血管密度减少。结论:放射线对皮瓣的损伤,同时表现在对细胞的损伤和对血管内皮细胞的损伤。建立随意皮瓣放射损伤模型,可为提高颌面颈部肿瘤外科综合治疗的预后效果提供研究平台。
Objective： To build an animal model of radiation injury on random flap, and make pathological research on it. Methods： Randomly divide 60 normal Wistar rats into 5 groups, and build random flap animal models and radiation injury models. Watch on those models clinically. Infuse Chinese gelatin ink into the flaps and make pathogicalscopy on the flaps. Results： Animal model of radiation injury on random flaps is constructed successfully, verifying that as the dose of radioactive ray increases the density of vessels decrease. Conclusions： Radiation injury on flaps is manifested both on cells and VEC. Through the construction of animal models of radiation injury on random flaps, we can build a platform on which the prognosis of combined therapy on malignant tumor of maxilla and neck can be investigated.
出处
《中华老年口腔医学杂志》
2007年第1期23-25,共3页
Chinese Journal of Geriatric Dentistry
基金
长春市科委科技基金支持项目(03-198S37)
关键词
皮瓣
随意皮瓣
血管
血管密度
损伤
放射损伤
flaps
random flap
blood vessels
density of blood vessels
injuries
radiation injuries
