摘要
目的:观察抗髓过氧化物酶(MPO)抗体在不同肾小球疾病中的发生情况,初步探讨抗中性粒细胞胞浆抗体在肾小球疾病中的临床意义。方法:用ELISA法测定35例健康体检者和349例各种原发性、继发性肾小球疾病患者的血清抗MPO抗体水平。结果:与正常对照组比较,隐匿性肾炎、乙肝相关性肾炎、慢性肾炎、肾病综合征及终末肾脏病血透患者抗MPO抗体水平差异无显著性(P>0.05);狼疮性肾炎和紫癜性肾炎抗MPO抗体浓度最高,与正常对照组和其余各肾脏病组比较其差异有显著性(P<0.05)。各种肾小球疾病中抗MPO抗体阳性率0%～23.81%,正常对照组、乙肝相关性肾炎和隐匿性肾炎中均未见抗MPO抗体阳性病例。结论:抗MPO抗体在各种肾小球疾病中的发生率为5.73%,继发性肾小球疾病以狼疮性肾炎抗MPO抗体水平及阳性率最高,抗MPO抗体可用于狼疮性肾炎和紫癜性肾炎与乙肝相关性肾炎和隐匿性肾炎临床鉴别诊断的重要参考指标。
Objective：To observe the positive rate of anti-myeloperoxidase （MPO） antibody in different kinds of primary and secondary glomerular diseases, to explore the clinical significance of anti-neutrophilic cytoplasmic autoantibody. Methods： The levels of serum anti-MPO antibody of 349 patients with kinds of primary or secondary renal glomerular diseases and 35 control subjects were measured by enzyme-linked immunosorbent assay.Results：Compared with the control group, the levels of serum anti-MPO antibody in patients with latent glomerulonephritis,hepatitis B virus associated glomerulonephritis（HBV-GN）,chronic glomerulonephritis,nephrotic syndrome or chronic renal failure had no significant difference （P 〉 0.05 ）.The levels of serum anfi-MPO antibody in patients with lupus nephritis（LN）and purpuric glomerulonephritis had significantly increased（P〈 0.01）.The level of plasma anti-MPO antibody of lupus nephritis and purpuric glomerulonephritis was the highest and much higher than that of normal control and patients with other glomerular diseases （P〈 0.05）.The positive rate of anti-MPO antibody in patients with various glomerular diseases was 0%-23.81%.There was no positive plasma anti-MPO antibody in healthy controls or patients with latent glomerulonephritis,or hepatitis B virus associated glomerulonephritis.Conclusion：The incidence of anti-MPO antibody in various glomerular diseases was 5.73%.The level and positive rate of plasma anti-MPO antibody in patients with lupus nephritis was the highest among secondary glomerular diseases.As an important mark for reference,anti-MPO antibody could be used to clinically differentiate lupus nephritis and purpuric nephritis from latent glomerulonephritis and Hepatitis B virus associated glomerulonephritis.
出处
《重庆医科大学学报》
CAS
CSCD
2007年第2期163-165,共3页
Journal of Chongqing Medical University
关键词
髓过氧化物酶
肾小球疾病
抗体
Myeloperoxidase
Glomerular diseases
Antibodies
