摘要
采用微管吸吮技术研究了正常健康人与慢性肺源性心脏病急性发作期患者红细胞在吸进微管的变形过程,采用二维V o igt模型拟合实验结果,定量地比较了正常人与肺心病患者红细胞膜的黏弹特性,结果表明:肺心病患者红细胞膜的弹性模量((6.970±1.050)×1-0 3dyn/cm)、黏性系数((0.936±0.475)×1-0 4dyn.s/cm)分别显著高于正常健康人的弹性模量((5.203±1.051)×1-0 3dyn/cm)、黏性系数((0.620±0.053)×10-4dyn.s/cm)。红细胞膜弹性模量与黏性系数增加、膜刚性增加,黏滞性增大。这可能是引起红细胞变形性降低乃致慢性肺源性心脏病急性发作期高黏滞血症的重要亚细胞机制。
The membrane viscoelasticity of erythrocyte taken from both normal subjects and patients with cor pulmonale during acute exacerbation was investigated using a micropipette aspiration technique. Experimental results were analysed with vogit viscoelaticity model based on pioneering theory of Chein et al. The results showed that the erythrocyte membrane elastic moduli （（6. 970±1. 050 ）×10^-3 dyn/cm） and viscous coefficients （（0. 936± 0. 242）×10^-4 dyn·s/cm） of the cor pulmonale patients was significantly higher than those of the normal subjects （（5. 203±1. 051）×10^-3 dyn/cm, （0. 620± 0. 053）×10^-4 dyn - s/cm）. The membrane elastic moduli,viscous coefficients, rigidity of erythrocyte, and viscosity were all increased. It may be the important subcellular mechanism to cause the decrease of erythrocyte deformability and hyperviscosity of blood in these patients.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2007年第1期182-185,共4页
Journal of Biomedical Engineering
关键词
慢性肺心病
红细胞膜
黏弹性
Cor pulmonale during acute exacerbation Erythrocyte membrane Viscoelasticity
