摘要
目的:研究对晚期肺癌化疗患者免疫功能的调节作用。方法:本研究应用生脉注射液配合化疗治疗晚期肺癌32例,观察患者外周血中IL-18、TH1、TH2细胞因子水平的变化。结果:单纯化疗组(32例)化疗后IL-18、TNF-a和IL-2明显下降(P<0.05),IL-4和IL-10明显升高。生脉注射液应用组(32例)化疗后IL-18、TNF-a、IL-2、IL-4和IL-10无明显变化。结论:生脉注射液对晚期肺癌化疗患者具有保护、增强免疫功能作用,这对中期肺癌患者的化疗后修复有一定意义。
Objective ：To investigate regulation effect of Shengraai injection on immunological function in patients with advanced lung cancer in chemical treatment procession. Methods： 32 patients with advanced lung cancer were enrolled in this study. Shenmai injection was used in these patients. Level of IL - 18 ,TH1 （TNF - α,IL -2 ）, and TH2 （IL-4,IL- 10） in the peripheral blood were detected by using an ELISA assay. Results： In the control group, the levels of IL- 18 ,TH1 （TNF- α,IL- 2） in the peripheral blood were all markedly decreased and TH2 （IL-4 ,IL- 10） were all markedly increased after chemical treatment compared with those before chemical treatment. In the Shenmai group, the levels of IL - 18 ,TH1 （ TNF - α, IL - 2 ） and TH2 （ IL - 4, IL - 10 ） did not change after chemical treatment compared with those before chemical treatment. Conclusion： Shengmai injection can protect and enhance immunological function in patients with advanced lung cancer in chemical treatment procession.
出处
《中华中医药学刊》
CAS
2007年第2期268-269,共2页
Chinese Archives of Traditional Chinese Medicine
基金
国家重点基础研究发展规划资助项目("973"项目)(2001CB510001)
关键词
生脉注射液
肺癌
化疗
TH1/TH2
细胞因子
免疫功能
调节
Shengmai injection
lung cancer
chemotherapy
Th1/Th2
cytokine
immunological function
regulation
