摘要
目的评估联合应用免疫球蛋白与乙肝疫苗对阻断乙肝母婴传播的效果,探索最佳阻断方案。方法将220例乙肝病毒表面抗原(HBsAg)、e抗原(HBeAg)双阳性的母亲及其所生新生儿分成3组,第一组母亲在分娩前三个月每月注射一次乙肝免疫球蛋白(HBIG)200IU/ml,出生婴儿按0、2周注射HBIG200IU/ml;第二组婴儿出生后按0、2周注射HBIG200IU/ml;第三组不使用HBIG。所有婴儿按国家免疫程序(0、1、6月)注射乙肝疫苗。对220名儿童进行3年血清学追踪观察(1、2、3岁)。结论联合应用免疫球蛋白与乙肝疫苗对阻断乙肝母婴传播的效果最佳。
Object To assess the efficacy of hepatitis B vaccine combined with immune globulin in infants born to HBsAg and HBeAg carrier mothers, find the best method to HBV interruption of perinatel transmission. Methods A total of 220 neonates born to HBsAg, HBeAg both positive mothers were divided into three groups： the mothers of the first group were vaccinated with HBIG（ 2001U 3 times at their last 3 months ） and their infants were also vaccinated with HBIG（ 200 IU at birth and 2 weeks 0, the infants of the second group were vaccinated with HBIG（ 2001U at birth and 2 weeks）, the infants of the third group weren＇ t vaccinated with HBIG, all the infants were vaccinated with5,5, 5big doses of Hepatitis B vaccine by 0, land 6 months schedule. They were all fllowed for 3 years after primary vaccination. Conclusion These results indicate that the efficacy of hepatitis B vaccine combined with HBIG was best at HBV interruption of perinatal transmission.
出处
《中国公共卫生管理》
2007年第1期86-87,共2页
Chinese Journal of Public Health Management
关键词
免疫球蛋白
乙肝疫苗
母婴阻断
效果
HBIG
Hepatitis B
HBV interruption of perinatal transmission
Efficacy.
