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前S1抗原诊断乙型肝炎病毒复制的临床探讨 被引量:4

Correlations of serum Pre-S_1 and HBeAg and HBV DNA in patients with chronic hepatitis B
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摘要 目的分析前S1抗原与乙型肝炎病毒血清复制指标之间的关系。方法对651例乙型肝炎病毒标志物阳性血清,检测其HBV DNA、HBeAg和前-S1,分析检出率及相关性。结果HBV DNA、前-S1在HBsAg、HBeAg、HB-cAb阳性组中的检出率分别达98.5%、97.0%,HBsAg、HBeAb、HBcAb阳性组中为63.0%、62.4%,HBsAg、HBcAb阳性组中为49.1%、45.4%。HBV DNA≥103拷贝/ml的399例中HBeAg和前-S1的阳性率分别为34.1%、95.7%;HBV DNA<103拷贝/ml的252例中HBeAg和前-S1的阳性率分别为0.9%、2.4%。HBV DNA与HBeAg的检出率差异有显著性,与前-S1的检出率差异无显著性。结论前-S1抗原较HBeAg更敏感地反映HBV复制的情况。 Objective To investigate the correlations of serum pre-S1 and HBeAg and HBV DNA in patients with chronic hepatitis B. Methods 651 patients with chronic hepatitis B were included in the study. Serum samples were detected with the quantitative determination of HBV DNA by a quantitative PCR assay and detemination of pre-S1 protein by ELISA. Results The positive rates of HBV DNA and pre-S1 protein in patients with HBsAg/HBeAg/anti-HBc positive were 98. 5%and 97.0% ,respectively; in patients with HBsAg/anti-HBe/anti-HBc positive were 63.0%and 62.4%, respectively+ in patients with HBsAg/anti-HBc positive were 49.1% and 45. 4%, respectively. In samples with HBVDNA ≥10^3copies/ml, the positive rate of HBeAg and pre-S1 were 34. 1%and 95. 7%, while in sera with HBV DNA〈10^3copies/ml,the positive rate of HBeAg and pre-S1 were 0. 9% and 2.4%. Conclusion Pre-S1 is more sensitive than HBeAg in diagnosing viral replication in patients with chronic hepatitis B.
机构地区 解放军第
出处 《实用肝脏病杂志》 CAS 2007年第1期22-23,共2页 Journal of Practical Hepatology
关键词 乙型肝炎 前S1抗原 乙型肝炎病毒E抗原 HBV DNA Hepatitis B Pre-S1 Hepatitis B e antigen HBV DNA
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