摘要
目的探讨罗比卡因复合芬太尼行硬膜外病人自控镇痛(PCEA)对宫颈癌患者术后免疫功能的影响。方法40例宫颈癌根治术患者随机分为两组,每组20例。I组(试验组),罗比卡因复合芬太尼组;II组(对照组),罗比卡因复合吗啡组.分别于麻醉前(T0)、术毕2h(T1)、术后24h(T2)、术后72h(T3)采集外周静脉血,测定T淋巴细胞亚群及IL-2、IL-6水平。结果两组镇痛效果良好,与麻醉前比较,I组T淋巴细胞亚群及IL-2、IL-6水平各点之间差异无显著性(P>0.05);与I组比较,II组T1、T2的CD3+、CD4+和IL-2均明显下降(P<0.05)。结论罗比卡因复合芬太尼行PCEA对免疫的抑制作用较轻,镇痛效果良好,更适合宫颈癌患者术后镇痛。
[Objective] To explore the clinical effects of postoperative analgesia with compounds of Ropivacaine and Fentanyl on immuno-function in patients with cervical cancer. [Methods] Forty patients with cervical cancer undergoing hysterectomy were selected and divided into two groups： PCEA was made with 0.125% Ropivacaine and Fentanyl 0.25 nag in Group Ⅰ and with 0.125% Bupivacaine and Morphine 5 mg in Group Ⅱ. Peripheral venous blood was extracted before anesthesia and 2 h, 24 h, 72 h after operation and the concentration of IL-6, IL-2 and T cell subgroup were measured. [Results] The postoperative analgesia was good in beth groups. Compared with that before anesthesia, there was no significant difference in IL-6, IL-2 and T cell subgroup after operation in Group Ⅰ （P 〉0.05）. CD3^＋, CD4^＋, IL-2 in Group Ⅱ 2 h, 24 h after operation decreased significantly than that in Group i （P 〈 0.05）. [Conclusions] 0.125% Ropivacaine combined with low dosage of Fentanyl in PCEA has httle effect on immunofunction and makes good analgesia and is more suitable to be used in patients with cervical cancer.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2007年第2期195-197,共3页
China Journal of Modern Medicine
关键词
罗比卡因
芬太尼
免疫
硬膜外
镇痛
宫颈癌
Ropivacine
Fentanyl
immunity
epidural
analgesia
cervical carcinoma
