摘要
目的:采用可降解性生物材料壳聚糖短纤维增强聚己内酯(PCL)制备人工胸壁,重建犬缺损胸壁,探讨其用于临床修复胸壁缺损的可行性。方法:建立面积达10cm×10cm的两种犬胸壁缺损,实验组Ⅰ单纯切除肋骨(n=2),实验组Ⅱ整块切除包括肋骨骨膜、肋骨、肋间肌和壁层胸膜(n=8),分别用壳聚糖短纤维增强PCL板重建两种缺损胸壁,X线、胸部CT及组织学观察复合材料植入后犬胸壁组织的再生情况。结果:所有动物均存活,无手术和围手术期死亡,无胸壁塌陷及反常呼吸。实验组Ⅰ犬新生骨质沿人工胸壁表面生长,在PCL板与胸膜之间再生完整肋骨;实验组Ⅱ人工胸壁材料能够与周围胸壁肋骨及肌肉组织达到很好的结合,界面良好,固定牢靠。结论:可降解性壳聚糖纤维增强PCL复合材料具有良好的生物相容性,能够对缺损胸壁提供有效的支撑作用,值得进一步研究以应用于临床。
Objective： To investigate the application of a novel degradable biomaterial-short chitin fiber reinforced polycaprolactone （PCL） as a chest wall prosthesis, so as to assess its feasibility in clinical chest wall recomstruction. Methods： Two kinds of chest wall defects models （ 10 cm× 10 cm） were established in the present study, namely, group I with simple rib resection （n=2） and group II with full-thickness resection （the ribs, rib periosteum, intercostal muscle, parietal pleura, n=8）. The defects in both groups were repaired with short chitin fiber reinforced PCL plates. The implanted chest wall prosthesis and the regeneration of the chest wall tissue were dynamically observed postoperatively by X-ray, CT scanning, and histological examinations. Results： No operative/peri-operative death was observed in both groups; flail chest and paradoxical movement were not found in dogs. In group Ⅰ neogenetic bone tissues were found growing along the surface of chest wall prosthesis and new ribs appeared between prosthesis and parietal pleura. In group Ⅱ artificial chest wall prosthesis integrated tightly with chest wall ribs and muscle tissues around. Conclusion： Degradable chitin fiber reinforced PCL has fine biocompatibility and can provide effective support for chest walls, making it a promising biomaterial for chest wall reconstruction.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2007年第1期23-26,共4页
Academic Journal of Second Military Medical University
基金
上海市科学技术发展基金(024419076)~~
关键词
壳聚糖
聚己内酯
胸壁缺损
chitin
polycaprolactone
chest wall defects
