摘要
目的对35例采用颞浅动脉逆行插管灌注化疗的原发于上颌骨区的小涎腺恶性肿瘤病例进行研究。对化疗疗效、毒副反应及影响化疗近期疗效的因素进行分析。方法上颌骨区小涎腺恶性肿瘤患者35例,T312例,T423例;M032例,M13例(肺转移2例,纵隔转移1例)。化疗方案采用顺铂(cisplatin),吡柔比星(pirarubicin),5-氟尿嘧啶(5-fluorouracil)。其中7例患者因病变累及双侧上颌骨,而采用了双侧颞浅动脉插管颌内动脉灌注化疗。结果所有患者经颞浅动脉插管颌内动脉灌注化疗1周期后,PR22例(62.9%),NC9例(25.7%),PD4例(11.4%)。无CR病例。毒副反应以血液毒性为主。未见其他毒性反应。无因毒性反应而延迟手术的病例。结论本文资料表明,颞浅动脉灌注化疗治疗原发于上颌骨区的小涎腺恶性肿瘤具有良好的临床疗效,RR62.9%。吡柔比星(THP)与PDD及5-Fu有协同增效作用可能是本组病例疗效较高的原因之一。对转移患者,灌注区原发病灶缩小大于转移灶,提示动脉灌注化疗的高效性。病理类型、既往手术或放疗史是影响化疗效果的重要因素。
Objective： To report 35 cases of maxillar minor salivary gland malignant carcinoma which treated with superficial temporal artery injection, and analyz the factors that influence the chemotherapy curative effect, toxicity. Methods： Thirty five cases of maxillas minor salivary gland malignant carcinoma including 16 cases of males and 19 cases of females with ages from 23 to 69 . Clinical stages ： T stages ： 12 cases of T3 , 23 cases of T4. M stages ： 32 cases of M0, 3 cases of M1 （with 2 cases of lung and 1 case of mediastina）. Chemotherapy regimen- cisplatin（ 13 ～ 25） mg· m^-2 ,d（1-5） ;pirarubicin 10mg· d^-1 ,d（1-5） ; 5 - fluorouracil （300mg ～ 600） mg·m^-2 ,d（1-5）. 7 cases use both side of superficial temporal artery because tumour involved both side of maxillas. Results ： After one cycle of chemotherapy, among all the patients, PR： 22 cases（62.9% ） ,NC： 9 cases（25.7% ） ,PD- 4 cases（ 11.4% ）. No CR cases. The main toxicity was blood reaction. No operation delayed for the reason of toxicity. Conclusion： Superficial temporal artery injection chemotherapy has a high effect in treating maxillar minor salivary gland malignant carcinoma. Pirarubicin can enhance the action of cisplatin and 5 - fluorouracil. This maybe the cause of the high curative rate. For the patients who have metastatic carcinoma , the tumor in artery injection area shrinks more than that in other area. This indicates that artery injection chemotherapy has a higher effect . Pathologic type, having been operated and having radiotherapy are the main factors which influence the effect .
出处
《现代肿瘤医学》
CAS
2007年第2期181-182,共2页
Journal of Modern Oncology
基金
西安交通大学自然科学基金资助项目(编号:XJJ2001010)
关键词
上颌骨
小涎腺恶性肿瘤
化疗
maxillar
minor salivary gland malignant carcinoma
chemotherapy ModernOncology
