摘要
目的探讨营养,年龄及性别等因子对II型糖尿病动物模型--KK/Upj-Ay/J小鼠血糖的影响。方法尾部取血,用血糖仪测定实验组和对照组动物的血糖并进行实验分析。结果实验组血糖值明显高于对照组;实验组发病动物的比例也明显高于对照组动物;对照组8月龄小鼠血糖值低于糖尿病的发病标准;实验组年龄对动物的血糖影响较小;实验组和对照组性别基本不影响动物的血糖。结论(1)在同样携带Ay黄色肥胖糖尿病基因的遗传作用的条件下,饲料中的营养成分是影响小鼠血糖的主要因素,(2)动物的年龄是影响血糖的另一主要因素。(3)性别对动物血糖的影响不大。
Objective The effect factors on blood glucose of KK/Upj-A^y/J mice with nutrition, age and sex. Methods Tail blood with experimental group mice and comparative group mice were measured by blood glucose detector. Results Either blood glucose level or ratio to all mice, experimental group were significantly highter than that of comparative group. On comparative group, blood glucose level is low on 8 months old. On the other hand, experimental group mice in both sex, age have a few bearing on blood glucose level. The sex has almost not an influence on all animal experiment. Conclusion I .nutrition components is main factors which affect blood glucose at same genetic background with A^ygene; 2.Another effect factor is the age of the mice; 3.The sex is not an important factor to blood glucose in the KK/Upj-A^y/J mice.
出处
《中国比较医学杂志》
CAS
2007年第1期15-17,共3页
Chinese Journal of Comparative Medicine
