摘要
目的探讨肝移植术后患者人类巨细胞病毒(HCMV)感染的较好的诊治方法。方法回顾分析2003年6月￣2006年6月进行的78例同种异体肝移植病例的临床资料。结果发生人类巨细胞病毒感染18例,出现发热12例,肺部感染5例,黄疸2例,6例无明显症状。经更昔洛韦治疗后,18例患者HCMV抗体、PP65和HCMV-DNA转变为阴性。结论肝移植后HCMV感染与多种因素有关,积极预防、早期治疗是至关重要的,HCMV抗体、PP65和HCMV-DNA的应用能够对HCMV感染患者作出早期诊断,指导治疗。传统治疗与先驱性治疗其并发症相比较无明显差异。但先驱性治疗有针对性,能降低耐药的发生率,避免药物的毒性反应,有利于病人的康复。
[Objective] To discuss the better diagnosis and treatment methods of human cytomegalovirus infection after iiver transplantation. [Methods] To retrospectively analyze 78 cases clinical data of homogeneity variant liver transplantation during June 2003 and June 2006. [Results] 18 cases had human cytomegalovirus infection, 12 cases had fever, 5 cases had pulmonary infection, 2 cases had jaundice, 6 cases had no obvious symptoms. After treated with ganciclovir, HCMV-IgM, PP65 and HCMV-DNA of 18 cases transformed to negative. [Conclusions] HCMV infection after liver transplantation is related with many factors, active prevention and early treatment is very important, application of HCMV-IgM, PP65 and HCMV-DNA can lead to early diagnosis and guide treatment to HCMV infection patients. Compared with traditional treatment, complication of pre-emptive treatment has no obvious difference, but pre-emptive treatment has pertinency, can degrade drug fast rate, avoid toxic reaction of drugs and be in favor of patient recovery.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2007年第1期73-75,79,共4页
China Journal of Modern Medicine
关键词
肝移植
巨细胞病毒感染
诊断
治疗
liver transplantation
cytomcgalovirus infection
diagnosis
treatment
