摘要
本文采用阴道内放置米索前列醇进行足月妊娠引产，其目的在于研究米索前列醇的引产效果及使用安全性。对１１０例符合引产指征的足月妊娠妇女，随机分为二组；二组妇女在年龄、孕周、孕产次及宫颈Ｂｉｓｈｏｐ评分等方面条件相似，分别采用阻道内放置米索前列醇引产（研究组）和静脉点滴催产素引产为（对照组）。结果：用药后宫颈Ｂｉｓｈｏｐ评分研究组由原５．９８分提高至９．４８分，对照组由原６．１６分提高至８．５５分，两组宫颈Ｂｉｓｈｏｐ评分平均变化相比有极显著差异（Ｐ＜０．００１），用药至分娩时间研究组为９．０小时较对照组为１４．４小时明显缩短（Ｐ＜０．００１），自然分娩率研究组为７９％，对照组为４６％（Ｐ＜０．０５），而产后出血，新生儿Ａｐｇａｒ评分及用药副作用等两组相比均无显著差异（Ｐ＞０．０５），提示：阴道内放置米索前列醇是一种安全有效的引产方法。
his prospective study was designed to assess the efficacy and safety of intravaginalmisoprostol for labor induction. Pregnants having an indication for induction of labor wererandomized to one of the two induction methods:intravaginal misoprostol(50μg)or intra-venous oxytocin drip,The two groups were matched with maternal age,gestational age andBishop score. The Bishop score improvement was of great significance between the twogroups in favour of n1isoprostol,changing from 5.98 to 9. 48 versus 6.16 to 8.55).Mean in-duction-to-delivery interval was 9.0 hours in the study group,and 14.4 hours in the controllgroup.(P<0.001).The success rate for vaginal delivery was significantly higher in themisoprostol group(79%)compared with the oxytocin group(46%),prospectively,P<0.005,While neonatal Apgar scores at one and five minutes,postpartum hemorrhage and drugside-effects were of no significance between the two groups,Intravaginal misoprostol may bean effective and safe method for labor induction.
出处
《上海医学》
CAS
CSCD
北大核心
1996年第12期687-690,共4页
Shanghai Medical Journal
关键词
米索前列醇
催产素
足月妊娠
引产
Misoprostol
Oxytocin
Term pregnancy
Labor induction.
