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蛋白质组学技术在泛素-蛋白酶体系统研究中的应用

Application of proteomic techniques in the research of ubiquitin-proteasome system
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摘要 泛素-蛋白酶体系统(ubituitin-proteasome system,UPS)是一条高效的、具有选择性并依赖能量的蛋白降解途径。目前应用蛋白质组学技术的重要研究工具之一质谱(mass spectrometry,MS)技术研究UPS系统还处于起步阶段。本综述主要介绍了应用蛋白质组学技术研究UPS系统的研究现状以及存在的问题。 Protein degradation via ubiquitin-proteasome system (UPS) is carried out with a wide variety of signalling pathways, from cell cycle and transcription to development. The mass spectrometry-based proteomics techniques are powerful tools in the research of UPS. The recent advance in the study of UPS by proteomics techniques is briefly reviewed.
出处 《基础医学与临床》 CSCD 北大核心 2007年第1期1-7,共7页 Basic and Clinical Medicine
基金 国家自然科学基金(20675088)
关键词 泛素-蛋白酶体系统 蛋白质组学 质谱 蛋白酶体 ubiquitin-proteasome system proteomics mass spectrometry proteasome
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