摘要
观察了２７例高血压病（ＰＨＴ）、１９例冠心病（ＣＨＤ）患者和４０例正常对照（ＮＣ）者血浆脂蛋白（ａ）（Ｌｐ（ａ））的水平，并分析了各组Ｌｐ（ａ）与其它脂类的相关性。结果显示，ＰＨＴ组Ｌｐ（ａ）水平为２４０．５±１２２．４ｍｇ／Ｌ，ＣＨＤ组为２２０．７±１２６．５ｍｇ／Ｌ，两组均显著高于ＮＣ组的１６６．５±７６．１ｍｇ／Ｌ（分别为Ｐ＜０．０１和Ｐ＜０．０５，血浆Ｌｐ（ａ）与甘油三酯ＴＧ）、总胆固醇（ＴＣ）、载脂蛋白Ａｌ（Ａｐｏａｌ）、载脂蛋白Ｂ（ＡｐｏＢ）和ＡｏｏＡｌ／ＡｐｏＢ的比值之间均无显著相关性（Ｐ＜０．０５）。表明：Ｌｐ（ａ）可通过干扰脂质代谢和纤溶过程而发挥其致动脉粥样硬化（ＡＳ）作用，它是ＣＨＤ的独立危险因子。Ｌｐ（ａ）可能在ＰＨＴ的发生与发展过程中也起一定作用。
The levels of plasma lipoprotein(a)(Lp(a)),in 27 patients with hypertention,19 patients with coronary heart disease(CHD)and 40 normal controls were oberved,and its correlation with the level of triglyceride(TG),total cholesterol(TC),apolipoprotein AI(ApoAI),apolipoprotein B(ApoB) and the value of ApoAI/ApoB were studied.The results showed that the plasma Lp(a)levels in patients with hypertention and CHD were 240.5 ± 122.4 mg/L and 220.7±126. 5 mg/L,both being significantly higher than that in normal controls which was 166.5 ± 76.1mg/L,(P<0.01 andP < 0.05,respectively).There was no signification correlation between Lp(a)and any other index observed(all P>0.05).It is considered that the possible channels through which Lp(a)exerts its atherogenic effect are disturbing the lipid metabolism in arterial walls and the fibrinolytic system,prompting the formation of microthrombus and atherosclerotic plaques.There might exist a certain relationship between Lp(a)and hypertention which needs further studies.The level of plasma Lp(a)does not change with other lipids and is an independent risk factor of CHD.
关键词
高血压
冠心病
脂蛋白
血液
hypertension/BL
coronary disease/BL
lipoproteins
