摘要
目的进一步探讨抗核包膜蛋白抗体的临床意义。方法对48例原发性胆汁性肝硬化（PBC）及1881例对照组血清标本以间接免疫荧光法检测抗核抗体（ANA），选择抗核包膜蛋白抗体阳性的病例进行临床回顾性分析。结果1929例血清标本中50例抗核包膜蛋白抗体阳性，相关疾病包括PBC等多种系统性自身免疫病。抗核包膜蛋白抗体在PBC患者组中的阳性率为39．58％，明显高于其他系统性自身免疫性疾病组（x^2=134，P〈0．01）及非自身免疫性肝脏疾病组即；109，P〈0．01），诊断PBC的特异性为98．35％。结论抗核包膜蛋白抗体与多种疾病相关，这种现象可能与其靶抗原的异质性相关。但其对诊断PBC价值较高。
Objective To further investigate the clinical significance of anti-nuclear envelope protein autoantibodies. Methods Serum samples of 48 primary biliary cirrhosis （PBC） and 1881 control cases were screened for anti-nuclear antigens （ANA） by indirect immunofluorescence （IIF）. Patients selected positive with anti-nuclear envelope protein autoantibodies were clinically retrospoctively reviewed. Results Fifty of the 1929 ANA positive cases detected ANA were positive for anti-nuclear envelope pi＇otein autoantibodies. The autoantibodies could exist in many kinds of diseases, including PBC, and various systemic autoimmune diseases. Prevalence of the autoantibodies in PBC patients was 39.58%, which was significantly higher than that in other systemic autoimmune diseases patients （x^2=-134, P〈0.01 ） and other liver diseases patients （x^2=-109, P〈 0.01）, and their specificity for PBC was 98.35%. Conclusion Anti-nuclear envelope protein autoantibodies are associated with various diseases, which may be related with its various target antigens. It has important implication for clinical diagnosis of PBC.
出处
《中华风湿病学杂志》
CAS
CSCD
2007年第1期27-30,共4页
Chinese Journal of Rheumatology
关键词
肝硬化
胆汁性
自身免疫疾病
抗核包膜蛋白抗体
间接免疫荧光法
Liver cirrhosis, biliary
Autoimmune disease
Anti-nuclear envelope protein autoanti- bodies
Indirect immunofluorescence
