摘要
目的探讨螺旋CT灌注成像监测肝硬化不同阶段门静脉压力变化的应用价值。方法复合法建立Sprague-Dawlay大鼠肝硬化模型,分别对肝硬化前期大鼠17只,早期18只,进展期12只和正常大鼠13只行单层螺旋CT肝脏动态灌注扫描。去卷积法计算肝脏各血流灌注参数,同时运用生理多导仪测量门静脉自由压(freeportalpressure,FPP)。结果①实验组FPP与门静脉灌注量(portalvenousperfusion,PVP)、总肝灌注量(totalhepaticbloodperfusion,THBP)之间呈负相关、与肝动脉灌注指数(hepaticarterialperfusionindex,HPI)、平均通过时间(meantransittime,MTT)呈正相关。其中FPP与PVP的相关性最好(r=-0.845),两者关系的直线回归方程为Y=20.671-3.195X。②利用FPP与PVP直线回归方程Y=20.671-3.195X计算47只肝硬化大鼠的门静脉压力为16.090±2.150cmH2O与实测的16.108±3.662cmH2O有良好的相关性(r=0.823P<0.01)。结论CT灌注成像为无创、有效地监测肝硬化不同时期的门静脉压力提供了新途径。
Objective To evaluate spiral CT perfusion in assessing portal vein pressure in rats with different stages of liver cirrhosis. Methods Seventeen rats with early stage of liver cirrhosis, 18 with intermediate stage, 12 with advanced stage, and 13 healthy rats as a control group were selected and recieved hepatic perfusion on a single-row spiral CT scanner. The parameters of hepatic perfusion were calculated using the deconvolution method. The portal vein pressure was measured by multi-physiographer. Results ① In study group, the PVP （portal venous perfusion） and THBP （total hepatic blood perfusion） were negatively correlated with FPP, while positively correlated with the HPI （hepatic perfusion index） and MTT （mean transit time）. The FPP had a close relation with PVP. The equation, Y = 20.671-3.195X, could be conducted with linear regression analysis. ② According to the linear regression equation mentioned above, the FPP in 47 rats were 16.090±2.150 cmH2O, which was highly correlated with the observed value 16.108±3.662 cmH2O （r = 0.823 P 〈 0.01）. Conclusion CT peffusion is a new non-invasive and efficient modality for assessment of the portal pressure in liver cirrhosis in various stages.
出处
《影像诊断与介入放射学》
2006年第6期280-283,共4页
Diagnostic Imaging & Interventional Radiology
基金
国家自然科学基金(30270417)
广东省医学科研基金(A2004174)
