摘要
胆固醇酯转运蛋白(CETP)介导血浆脂蛋白之间胆固醇酯、磷脂和三酰甘油的转运,直接关联各种脂蛋白分子的组成、大小和浓度,与动脉粥样硬化的发生发展密切相关。CETP基因存在着多种变异,影响CETP浓度和活性,引起机体的脂代谢异常。作者就有关CETP基因变异与脂类参数、心血管疾病发生风险性关系的研究进展作一综述。
Cholesteryl ester transfer protein （CETP） plays an important role in the transfer and exchange of cholesteryl esters, phospholipid and triacyglycerols. It affects lipid composition, concentration, particle size and function of lipoproteins, partcipating in the development of atherosclerosis. The role of CETP in human atherosclerosis has not been fully elucidated. Gene variations of the CETP were associated with altered CETP plasma levels and activity, lipid metabolism disorder. The relationships between CETP gene variation, lipid parameters and cardiovascular risk was reviewed.
出处
《医学研究生学报》
CAS
2007年第1期76-79,共4页
Journal of Medical Postgraduates
基金
国家自然科学基金资助项目(批准号:30471649)
江苏省人类功能基因组学重点实验室开放课题(批准号:200040928)
