摘要
目的评价异维A酸软膏治疗寻常痤疮的疗效和安全性。方法入组寻常痤疮患者240例，分别应用0．05％异维A酸软膏或0．05％维A酸乳膏，每晚1次，疗程8周。通过炎性皮损和非炎性皮损计数观察疗效，评价红斑、脱屑、烧灼感等局部不良反应。结果治疗8周，试验组皮损总数目从45．52±19．80减少至16．24±16．10，对照组皮损总数目从44．00±19．13减少至12．24±11．34，试验组有效率为69．75％，对照组有效率为80．51％，差异无统计学意义（P〉0．05），两组局部不良反应发生率差异无统计学意义（P〉0．05）。结论异维A酸软膏治疗寻常痤疮安全有效，其临床疗效及皮肤耐受性同0．05％维A酸乳膏相似。
Objective To assess the efficacy and safety ofisotretinoin ointment 0.05% in the treatment of ache vulgaris. Methods A total of 240 patients were enrolled into the study. The patients were instructed to apply isotretinoin ointment 0.05% or retinoic acid cream 0.05% once daily in the evening for 8 week. The treatment efficacy was evaluated by the counting of non-inflammatory and inflammatory lesions and global evaluation of improvement. Cutaneous tolerance was assessed by observation of erythema, scaling and burning. Results After treatment for 8 weeks, the counts of lesion were decreased fi＇om 45.52 ±19.80 to 16.24 ± 16. 10 in study group, and from 44.00±19.13 to 12.24±11.34 in controls. The response rate was 69.75% in study group and 80.51% in control group. There was no significant difference in response rate between two groups, so was in the local adverse effect （ P 〉 0.05 ）.Conclusions Isotretinoin ointment, which had similar clinical efficacy and cutaneous tolerance with retinoic acid cream 0.05%, is safe and effective to treat acne vulgaris.
出处
《国际皮肤性病学杂志》
2007年第1期4-6,共3页
International Journal of Dermatology and Venereology
关键词
痤疮
寻常
异维A酸
维A酸
Ache vulgaris
Isotretinoin ointment
Retinoic acid cream
