摘要
目的探讨胃镜检出的胃癌临床演变趋势。方法以该院1975年1月至2004年12月30年间经胃镜检查和病理证实的胃癌437例为研究对象。根据发现时间的先后分为三组:1组(1975年至1984年)66例,2组(1985年至1994年)198例,3组(1995年至2004年)173例。按照胃癌的胃镜检出率、性别、年龄、发生部位、组织学类型等进行统计分析。结果胃癌的胃镜检出率依次降低,分别为1组4.5%,2组2.6%,3组1.7%,三组之间比较,P<0.005。胃癌男女之比三组接近,P>0.05。贲门癌发生率三组依次升高,分别为1组13.6%,2组21.7%,3组26.0%,1组与3组比较差异有统计学意义(P<0.05);而胃窦癌发生率三组依次降低,分别为1组43.9%,2组30.3%,3组30.1%,2组、3组与1组比较差异均有统计学意义(P<0.05)。高、中分化腺癌1组为36.4%,2组为30.3%,3组为30.6%,低分化腺癌1组、2组、3组分别为45.5%、54%、50.9%,未分化癌1组、2组、3组分别为7.6%、4.5%、4.0%,每种组织学病理类型各组之间差异无统计学意义(均P>0.05)。结论胃癌的胃镜检出率逐年降低,男女之比改变不大,胃癌发生部位有逐渐向近端上移趋势,高、中分化腺癌和未分化癌呈现逐年降低趋势,低分化腺癌有轻度上升趋势,但均不明显,尤其是近20年。
Objective To study the clinical changing trend in gastric cancer. Methods 437 cases of gastric cancers diagnosed by gastroscopy and pathology during the period from January 1975 to December 2004 were selected. The patients were divided into three groups according to the diagnosis time. Group Ⅰ comprised 66 patients from 1975 through 1984,group Ⅱ consisted of 198 patients from 1985 through 1994,and group m included 173 patients from 1995 through 2004. Statistical comparison analysis was performed according to the gastroscopically detected rate, sex ratio, locational distributions, histological type of gastric cancer. Results The gastrocopically detected rate of gastric cancer was 4.5 % in group Ⅰ ,2.6% in group Ⅱ ,and 1.7 % in group Ⅲ ,respectively, P 〈 0. 005. There was no change in the male：female ratio among three groups. There was an increase in the proportion of cardia carcinoma in group m （26 % ） compared with group Ⅰ （13.6 % ） and group Ⅱ （21.7 % ）, with a corresponding decrease in the proportion of antral carcinoma in group m （30.1% ） compared with gorup Ⅰ（43.9 % ） and group Ⅱ（30.3%）,the proportion of well and moderate adenocarcinoma in group Ⅰ,Ⅱ andⅢ was 36.4% ,30.3% and 30.6 %, respectively（ P 〉 0.05）. While poor adenocarcinoma in the three groups was 45.5 % ,54 % and 50.9 %, respectively（ P 〉0.05）. Whereas the incidence rates of undifferentiated carcinomas and of other histological types remained quite stable. Conclusions The gastroscopically deteceted rate of gastric cancer decrease in this period. The male：female ratio doesn＇t change significantly. There is a trend in location of gastric cancer towards proximal stomach. The proportions of well-moderate adenocarcinoma and undifferentiated cancer decrease with an increase in the proportion of poor differentiated adenocarcinoma. But there is no significant difference among them, especially in recent twenty years.
出处
《中国基层医药》
CAS
2006年第12期2029-2031,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
胃癌
变化趋势
gastric cancer
Changing trend
