摘要
目的:研究不同剂量辛伐他汀对高血压病患者血管活性物质的影响。方法:将90例高血压患者按随机原则分别入选常规治疗组(30例)和辛伐他汀治疗组,前者不接受任何调脂药物治疗,后者分别接受20 m g/d(30例)和40m g/d(30例)辛伐他汀治疗8周。测定各组患者治疗前后内皮素、血管紧张素Ⅱ、一氧化氮、降钙素基因相关肽和血脂水平。结果:经8周的治疗,20 m g辛伐他汀使血浆内皮素与血管紧张素Ⅱ水平降低、血压下降,而一氧化氮、降钙素基因相关钛水平上升,但与常规治疗组比较差异无统计学意义;40 m g他汀治疗组疗效则明显优于常规治疗组,两组间比较差异有统计学意义(P<0.05)。40 m g辛伐他汀治疗使内皮素、血管紧张素Ⅱ水平降低与LDL-C下降百分数之间无相关关系,而一氧化氮、降钙素基因相关钛水平的上升与LDL-C的下降有良好的相关性。结论:较大剂量辛伐他汀能够改善高血压患者血管活性物质的水平。
Objective To observe the effects of different doses of simvastatin on plasma vasoaction substances in hypertensive patients. Methods Ninety patients with essential hypertension were randomly separated into three groups. Thirty patients in group A were given routine therapy（ACEI and CCB） ; Thirty patients in group B were given routine therapy and 20 mg simvastatin once daily for 8 weeks ; Thirty patients in group C were given routine therapy and 40 mg simvastatin once daily for 8 weeks. The levels of endothelin, angiotension Ⅱ , nitric oxide, calcitonin gen-related peptide were measured. Results After 8 weeks treatment, nosignificant difference in endothelin, angiotension Ⅱ , nitric oxide and calcitonin gen-related peptide between 20 mg/d simvastatin group and control group were found. However, 40 mg/d simvastatin significantly decreased endothelin and angiotension Ⅱ were markedly increased in nitric oxide and calcitonin gen-related peptide. There was no relation between the decreased magnitude of endothelin, angiotension Ⅱ and that of LDL-C. The decreased in LDL-C was negatively related to nitric oxide and calcitonin gen-related peptide. Conclusion High dosage simvastatin improves the levels of plasma vasoactive substances along with decrease in blood pressure.
出处
《实用诊断与治疗杂志》
2007年第1期20-22,24,共4页
Journal of Practical Diagnosis and Therapy
关键词
高血压
辛伐他汀
内皮素
一氧化氮
血管紧张素Ⅱ
降钙素基因相关肽
Essential hypertension
simvastatin
endothelin
nitric oxide
angiotension Ⅱ
calcitonin gen-related peptide
