摘要
脓毒症的发生与机体免疫功能紊乱密切相关。随着脓毒症的进展,机体可能经历免疫抑制状态,表现为淋巴细胞的增殖能力下降,呈现以Th2型反应为主的免疫反应、大量淋巴细胞凋亡以及非特异性免疫功能障碍等,从而导致机体对病原体的易感性明显增加。近年来关干树突状细胞、调节性T细胞与脓毒症关系方面的研究渐成热点。深入探讨脓毒症中免疫功能紊乱的病理生理基础,可进一步阐明脓毒症的发病机制,并有针对性地制定相关调理策略,为其预防和治疗开拓新的思路。
Sepsis is the leading cause of morbidity and mortality in critically ill patients in intensive care units, increasing data have revealed significance of immune function disorder in sepsis and septic shock. With the development of sepsis, a phase of immune suppression could be evident in both clinical as well as animal studies, showing remarkable reduction in lymphocytic reproductive activity and predominant Th2 immune response. Sepsis causes a marked apoptosis-induced depletion of lymphocytes and a series of nonspecific immunity functional impairment. These changes may compromise the ability of the patient to eradicate the primary infection and predispose to secondary nosocomial infections. Recent study indicates dendritic cells and regulatory T cells respond to sepsis with considerable effect. Such new understanding of the pathophysiology of the disease might lead to novel immunomodulatory strategies in the treatment of sepsis.
出处
《创伤外科杂志》
2007年第1期4-7,共4页
Journal of Traumatic Surgery
基金
国家重点基础研究发展规划项目(2005CB522602)
国家杰出青年科学基金资助课题(30125020)
关键词
脓毒症
细胞免疫
免疫调理
sepsis
cell-mediated immunity
immunomodulation
