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肾功能不全对充血性心力衰竭患者预后的影响 被引量:4

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摘要 目的观察充血性心力衰竭(CHF)患者肾功能不全发生率及肾功能不全对CHF患者住院期间病死率的影响。方法收集NYHA心功能Ⅲ,Ⅳ级CHF患者的临床资料,根据患者血清肌酐水平分为肾功能正常组、肾功能不全代偿组和肾功能不全失代偿组。结果CHF患者肾功能不全的发生率为35.5%。NYHA心功能Ⅳ级患者的血清Cr浓度明显高于NYHA心功能Ⅲ级患者(P〈0.01);在血清Cr浓度升高的患者中,NYHA心功能Ⅳ级的比例较高。而NYHA心功能Ⅲ级的比例较低(均P〈0.05),且血清Cr与B型脑钠肽(BNP)呈正相关(P〈0.01)。CHF患者住院期间的病死率在肾功能不全的患者明显升高(P〈0.01)。住院期间死亡患者的血清Cr水平明显高于好转的患者(P〈0.05)。Logistic回归分析显示:Cr的回归系数为0.01,优势比(OR)为1.01(P=0.007。95%CI:1.003—1.017),BUN的回归系数为0,088,OR为1.092(P=0.009,95%CI:1.022~1.167)。结论Cr,BUN分别是NYHA心功能Ⅲ,Ⅳ级的CHF患者住院期间死亡的危险因素,肾功能不全是NYHA心功能Ⅲ,Ⅳ级的CHF患者住院期间的死亡的独立危险因素。
出处 《广东医学》 CAS CSCD 北大核心 2007年第1期117-119,共3页 Guangdong Medical Journal
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