摘要
目的:了解我院2005年临床分离菌对常见抗生素的耐药状况。方法:对我院2005年各科室送检标本中培养分离出的1 377株条件致病菌进行分析。结果:1 377株临床分离菌中革兰阳性球菌占24．55％,革兰阴性杆菌占75．45％。耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)检出率分别占金黄色葡萄球菌和凝固酶阴性葡萄球菌的70．25％和65．71％,革兰阳性球菌对万古霉素和替考拉宁均敏感;在革兰阴性杆菌中,产超广谱β-内酰胺酶检出率在大肠埃希菌和肺炎克雷伯菌中分别占47．87％和52．86％,在非发酵菌中以铜绿假单胞菌和鲍曼不动杆菌最为常见,革兰阴性杆菌对美洛配能和亚胺培南具有很好的敏感性。结论:细菌耐药呈上升趋势,多重耐药日趋严重,开展细菌耐药监测和掌握细菌耐药变迁动态,对指导临床合理应用抗菌药物和有效控制院内感染具有重要意义。
OBJECTIVE： To study antibiotic resistance of bacteria isolated from clinical materials in the First People＇ s Hospital of Changzhou in 2005. METHODS：An analysis was conducted of 1 377 clinical isolated strains of conditional pathogenic bacteria, cultured and isolated out of specimens submitted for detection in 2005 by the clinical departments .RESULTS： Of the 1 377 clinical isolated strains,Gram- positive bacterium accounted for 24.55% and Gram- negative bacterium accounted for 75.45% .Methicillin- resistant Staphylococci（MRSA） and Micropenin- resistant coagulase negative Staphylococcus（MRCNS） had 70.25% and 65.71% positive rates respectively of S. aureus and coagulase negative Staphylococcus. Gram- positive bacteria were seen sensitive to both Vancomycin and Teicoplanin.The positive rates of ESBLs in Escherichia coli and Klebsiella pneumoniae were 47.87% and 52.86% respectively.P.aeruginosa and A.baumanuli were the main nonfermentable bacteria. Imipenem and Meropenem remained the most potent antibacterial agents against Gram- negative organisms. CONCLUSION ：Bacterial resistance rates are on the rise, and multi - drug resistance（MDR） is getting more serious.Great importance must be attached to bacterial resistance monitoring and enhanced awareness of related change patterns so as to provide guidance in rational clinical use of antibacterials and in effective control of nosocomial infections.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第2期125-127,共3页
China Pharmacy
关键词
细菌耐药性
抗菌药物
革兰阳性球菌
革兰阴性杆菌
Bacterial resistance
Antibacterial agents
Gram - positive bacterium
Gram - negative bacterium
